Source:http://linkedlifedata.com/resource/pubmed/id/19397268
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2009-5-22
|
| pubmed:abstractText |
Highly potent N-substituted delta-lactams have been rationally designed and synthesized by a concise route with a one-pot tandem reaction as key step. These iminosugars show weak inhibition of wild-type beta-glucocerebrosidase but 3- to 6-fold increases in mutant enzyme activity (N370S).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1520-4804
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
28
|
| pubmed:volume |
52
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3146-9
|
| pubmed:meshHeading |
pubmed-meshheading:19397268-Drug Design,
pubmed-meshheading:19397268-Gaucher Disease,
pubmed-meshheading:19397268-Glucosylceramidase,
pubmed-meshheading:19397268-Humans,
pubmed-meshheading:19397268-Imino Sugars,
pubmed-meshheading:19397268-Lactams,
pubmed-meshheading:19397268-Mutation, Missense,
pubmed-meshheading:19397268-Structure-Activity Relationship,
pubmed-meshheading:19397268-Substrate Specificity
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease.
|
| pubmed:affiliation |
State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|