Linked Life Data

19395455

Source:http://linkedlifedata.com/resource/pubmed/id/19395455

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pubmed-article:19395455pubmed:abstractTextComplement plays a major role in inflammation and thrombosis associated with systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). A cross-sectional retrospective analysis was performed to evaluate serum complement fixation on platelets and thrombotic incidence using banked sera and clinical data from patients with SLE (n = 91), SLE with antiphospholipid antibodies (aPL) or APS (n = 78) and primary aPL (n = 57) or APS (n = 96). In-situ complement fixation was measured as C1q and C4d deposition on heterologous platelets using an enzyme-linked immunosorbent assay approach. Platelet activation by patient serum in the fluid phase was assessed via serotonin release assay. Enhanced in-situ complement fixation was associated with the presence of IgG aPL and IgG anti-beta2 glycoprotein 1 antibodies (P < 0.05) and increased platelet activation (P < 0.005). Moreover, enhanced complement fixation, especially C4d deposition on heterologous platelets, was positively associated with arterial thrombotic events in patients with SLE and aPL (P = 0.039). Sera from patients with aPL possess an enhanced capacity for in-situ complement fixation on platelets. This capacity may influence arterial thrombosis risk in patients with SLE.lld:pubmed
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pubmed-article:19395455pubmed:authorpubmed-author:SalmonJ EJElld:pubmed
pubmed-article:19395455pubmed:authorpubmed-author:YinWWlld:pubmed
pubmed-article:19395455pubmed:authorpubmed-author:RoubeyR A SRAlld:pubmed
pubmed-article:19395455pubmed:authorpubmed-author:PeerschkeE...lld:pubmed
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pubmed-article:19395455pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:19395455pubmed:year2009lld:pubmed
pubmed-article:19395455pubmed:articleTitleSerum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies.lld:pubmed
pubmed-article:19395455pubmed:affiliationDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10029, USA. ellinor.peerschke@mountsinai.orglld:pubmed
pubmed-article:19395455pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19395455pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:19395455pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:19395455pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed