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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-4-27
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pubmed:abstractText |
Complement plays a major role in inflammation and thrombosis associated with systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). A cross-sectional retrospective analysis was performed to evaluate serum complement fixation on platelets and thrombotic incidence using banked sera and clinical data from patients with SLE (n = 91), SLE with antiphospholipid antibodies (aPL) or APS (n = 78) and primary aPL (n = 57) or APS (n = 96). In-situ complement fixation was measured as C1q and C4d deposition on heterologous platelets using an enzyme-linked immunosorbent assay approach. Platelet activation by patient serum in the fluid phase was assessed via serotonin release assay. Enhanced in-situ complement fixation was associated with the presence of IgG aPL and IgG anti-beta2 glycoprotein 1 antibodies (P < 0.05) and increased platelet activation (P < 0.005). Moreover, enhanced complement fixation, especially C4d deposition on heterologous platelets, was positively associated with arterial thrombotic events in patients with SLE and aPL (P = 0.039). Sera from patients with aPL possess an enhanced capacity for in-situ complement fixation on platelets. This capacity may influence arterial thrombosis risk in patients with SLE.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0961-2033
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19395455-Adult,
pubmed-meshheading:19395455-Antiphospholipid Syndrome,
pubmed-meshheading:19395455-Arterial Occlusive Diseases,
pubmed-meshheading:19395455-Blood Platelets,
pubmed-meshheading:19395455-Complement Activation,
pubmed-meshheading:19395455-Complement C1q,
pubmed-meshheading:19395455-Complement C4,
pubmed-meshheading:19395455-Cross-Sectional Studies,
pubmed-meshheading:19395455-Female,
pubmed-meshheading:19395455-Humans,
pubmed-meshheading:19395455-Immunoassay,
pubmed-meshheading:19395455-Incidence,
pubmed-meshheading:19395455-Lupus Erythematosus, Systemic,
pubmed-meshheading:19395455-Male,
pubmed-meshheading:19395455-Middle Aged,
pubmed-meshheading:19395455-Platelet Activation,
pubmed-meshheading:19395455-Retrospective Studies,
pubmed-meshheading:19395455-Risk Factors,
pubmed-meshheading:19395455-Thrombosis,
pubmed-meshheading:19395455-United States
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pubmed:year |
2009
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pubmed:articleTitle |
Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10029, USA. ellinor.peerschke@mountsinai.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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