Linked Life Data

1939518

Source:http://linkedlifedata.com/resource/pubmed/id/1939518

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-12-2
pubmed:abstractText
High intake of iodine inhibits iodide trapping, iodide organification, and hormone release from the human thyroid. We investigated whether iodine intake also affects thyroid blood flow, as was suggested by a recent study in euthyroid rats. With a Color Doppler device we made 14 consecutive Duplex-Doppler registrations of both superior thyroid arteries in 10 euthyroid volunteers during baseline iodine intake (1 week), iodine restriction (2 weeks), return to baseline (1 week), and iodine excess (1 week; 80 mumol sodium iodide/day). Vessel diameters and mean flow velocity were measured on videotape recordings by a "blinded" observer. Baseline iodide excretion was 0.88 +/- 0.38 (+/- SD) mumol/day. Mean flow velocity was 13.9 +/- 4.1 cm/s, and vessel diameter was 1.07 +/- 0.22 mm. Blood flow was 7.7 +/- 3.8 mL/min.superior thyroid artery. During the low iodine diet, excretion dropped to 0.49 +/- 0.16 mumol/day, and blood flow increased to 11.0 +/- 5.0 mL/min (P less than 0.001), remaining elevated (10.3 +/- 4.4 mL/min) during the second baseline diet. During high iodide intake, blood flow averaged 5.8 +/- 3.4 mL/min (P less than 0.001), and the expected decrease in thyroid hormone levels and increase in TSH were seen. We conclude that thyroid blood flow responds inversely, and independently from TSH, to changes in iodine intake in euthyroid humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1051-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Inverse relation between iodine intake and thyroid blood flow: color Doppler flow imaging in euthyroid humans.
pubmed:affiliation
Department of General Internal Medicine, University Hospital, Leiden, The Netherlands.
pubmed:publicationType
Journal Article