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rdf:type |
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lifeskim:mentions |
umls-concept:C0034693,
umls-concept:C0035647,
umls-concept:C0205199,
umls-concept:C0205314,
umls-concept:C0242485,
umls-concept:C0243067,
umls-concept:C0262950,
umls-concept:C0392762,
umls-concept:C0520510,
umls-concept:C0679622,
umls-concept:C0936012,
umls-concept:C2350281,
umls-concept:C2825501
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pubmed:issue |
8
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pubmed:dateCreated |
2009-11-20
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pubmed:abstractText |
Reconstruction of craniomaxillofacial defects is a challenge for surgeons and has psychological and functional burdens for patients. Undoubtedly, there is a need for improved biomaterials and techniques for craniomaxillofacial reconstruction. We assessed the potential regeneration of bone using three modifications of a novel composite and explored the validity of a new measurement using microcomputed tomography (micro-CT). We placed three different composite samples in calvarial defects in rats and analysed healing with micro-CT. The results showed that polycaprolactone (PCL) with phosphate glass fibre is promising for non-load bearing applications in the craniomaxillofacial region. Also, the new micro-CT measurement of the temporal characterisation of the mineralisation of bone (TCBM) has the potential to evolve into a reliable predictor of bony healing and its quality.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1532-1940
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
616-21
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pubmed:meshHeading |
pubmed-meshheading:19395133-Animals,
pubmed-meshheading:19395133-Biocompatible Materials,
pubmed-meshheading:19395133-Bone Density,
pubmed-meshheading:19395133-Bone Diseases,
pubmed-meshheading:19395133-Bone Regeneration,
pubmed-meshheading:19395133-Bone Substitutes,
pubmed-meshheading:19395133-Bone Transplantation,
pubmed-meshheading:19395133-Calcification, Physiologic,
pubmed-meshheading:19395133-Ceramics,
pubmed-meshheading:19395133-Glass,
pubmed-meshheading:19395133-Imaging, Three-Dimensional,
pubmed-meshheading:19395133-Phosphates,
pubmed-meshheading:19395133-Polyesters,
pubmed-meshheading:19395133-Rats,
pubmed-meshheading:19395133-Rats, Wistar,
pubmed-meshheading:19395133-Reconstructive Surgical Procedures,
pubmed-meshheading:19395133-Skull,
pubmed-meshheading:19395133-Time Factors,
pubmed-meshheading:19395133-Wound Healing,
pubmed-meshheading:19395133-X-Ray Microtomography
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pubmed:year |
2009
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pubmed:articleTitle |
Analysis of calvarial bone defects in rats using microcomputed tomography: potential for a novel composite material and a new quantitative measurement.
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pubmed:affiliation |
Oral and Maxillofacial Surgery, Leeds Dental Institute, University of Leeds, Leeds, UK. cefeoglu@yahoo.com
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pubmed:publicationType |
Journal Article,
Comparative Study
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