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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-5-11
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pubmed:abstractText |
A distinct subgroup of angiotensin II type 1 receptor (AT1R) blockers (ARBs) have been reported to suppress the development of hepatic steatosis. These effects were generally explained by selective peroxisome proliferator-activated receptor (PPAR) gamma modulating properties of ARBs, independent of their AT1R blocking actions. Here, we provide genetic evidence of the direct role for AT1R in hepatic steatosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoates,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR alpha,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/telmisartan
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1226-35
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pubmed:meshHeading |
pubmed-meshheading:19395110-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:19395110-Animals,
pubmed-meshheading:19395110-Base Sequence,
pubmed-meshheading:19395110-Benzimidazoles,
pubmed-meshheading:19395110-Benzoates,
pubmed-meshheading:19395110-Cell Line,
pubmed-meshheading:19395110-DNA Primers,
pubmed-meshheading:19395110-Fatty Liver,
pubmed-meshheading:19395110-Gene Silencing,
pubmed-meshheading:19395110-Humans,
pubmed-meshheading:19395110-Lipid Metabolism,
pubmed-meshheading:19395110-Liver,
pubmed-meshheading:19395110-Mice,
pubmed-meshheading:19395110-Mice, Inbred C57BL,
pubmed-meshheading:19395110-Mice, Knockout,
pubmed-meshheading:19395110-Oxidative Stress,
pubmed-meshheading:19395110-PPAR alpha,
pubmed-meshheading:19395110-PPAR gamma,
pubmed-meshheading:19395110-RNA, Messenger,
pubmed-meshheading:19395110-RNA, Small Interfering,
pubmed-meshheading:19395110-Receptor, Angiotensin, Type 1
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pubmed:year |
2009
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pubmed:articleTitle |
Deletion of angiotensin II type I receptor reduces hepatic steatosis.
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pubmed:affiliation |
Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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