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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-6-15
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pubmed:abstractText |
The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene may modulate the epilepsy phenotype. We investigated the impact of polymorphisms in the BDNF gene on clinical features in fragile X syndrome (FXS). In our study sample, the Met66 allele associated with epilepsy of finnish FXS men. Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS males to epilepsy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1872-6844
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-7
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pubmed:meshHeading |
pubmed-meshheading:19394799-Adolescent,
pubmed-meshheading:19394799-Adult,
pubmed-meshheading:19394799-Aged,
pubmed-meshheading:19394799-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:19394799-DNA Mutational Analysis,
pubmed-meshheading:19394799-Epilepsy,
pubmed-meshheading:19394799-Finland,
pubmed-meshheading:19394799-Fragile X Syndrome,
pubmed-meshheading:19394799-Humans,
pubmed-meshheading:19394799-Male,
pubmed-meshheading:19394799-Methionine,
pubmed-meshheading:19394799-Middle Aged,
pubmed-meshheading:19394799-Polymorphism, Genetic,
pubmed-meshheading:19394799-Valine,
pubmed-meshheading:19394799-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome.
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pubmed:affiliation |
Department of Biomedicine/Physiology, Biomedicum Helsinki, University of Helsinki, Helsinki FIN-00014, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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