|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-7-28
|
|
pubmed:abstractText |
The ubiquitously expressed basic helix-loop-helix transcription factor ITF-2B has an important role in differentiation processes, and its transcription is regulated by beta-catenin. The ITF-2 gene is located in the chromosomal region 18q21; allelic loss of this locus occurs in 70% of colorectal cancers. We analyzed the expression, regulation, and function of ITF-2B in colorectal carcinogenesis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1528-0012
|
|
pubmed:author |
pubmed-author:BehrensAndreaA,
pubmed-author:BolzChristianC,
pubmed-author:BommerGuido TGT,
pubmed-author:BrabletzThomasT,
pubmed-author:CsanadiEndyE,
pubmed-author:DietmaierWolfgangW,
pubmed-author:GökeBurkhardB,
pubmed-author:GerhardMarkusM,
pubmed-author:HerbstAndreasA,
pubmed-author:JungAndreasA,
pubmed-author:KolligsFrank TFT,
pubmed-author:KrieglLydiaL,
pubmed-author:RiesenbergRainerR,
pubmed-author:WolfIsabellaI,
pubmed-author:ZimmermannWolfgangW
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
137
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
639-48, 648.e1-9
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:19394332-Adenocarcinoma,
pubmed-meshheading:19394332-Adenomatous Polyposis Coli,
pubmed-meshheading:19394332-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors,
pubmed-meshheading:19394332-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:19394332-Cell Line, Tumor,
pubmed-meshheading:19394332-Cell Transformation, Neoplastic,
pubmed-meshheading:19394332-Chromosomes, Human, Pair 18,
pubmed-meshheading:19394332-Colorectal Neoplasms,
pubmed-meshheading:19394332-DNA-Binding Proteins,
pubmed-meshheading:19394332-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19394332-Genes, Tumor Suppressor,
pubmed-meshheading:19394332-Genetic Predisposition to Disease,
pubmed-meshheading:19394332-Humans,
pubmed-meshheading:19394332-Immunohistochemistry,
pubmed-meshheading:19394332-Loss of Heterozygosity,
pubmed-meshheading:19394332-Mutation,
pubmed-meshheading:19394332-Neoplasm Proteins,
pubmed-meshheading:19394332-Precancerous Conditions,
pubmed-meshheading:19394332-Transcription Factors
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition.
|
|
pubmed:affiliation |
Department of Medicine II, University of Munich, Munich, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
