Linked Life Data

19394221

Source:http://linkedlifedata.com/resource/pubmed/id/19394221

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-5-15
pubmed:abstractText
Combinatorial biocatalysis was applied to generate a diverse set of dihydroxymethylzearalenone analogs with modified ring structure. In one representative chemoenzymatic reaction sequence, dihydroxymethylzearalenone was first subjected to a unique enzyme-catalyzed oxidative ring opening reaction that creates two new carboxylic groups on the molecule. These groups served as reaction sites for further derivatization involving biocatalytic ring closure reactions with structurally diverse bifunctional reagents, including different diols and diamines. As a result, a library of cyclic bislactones and bislactams was created, with modified ring structures covering chemical space and structure activity relationships unattainable by conventional synthetic means.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3059-62
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Application of combinatorial biocatalysis for a unique ring expansion of dihydroxymethylzearalenone.
pubmed:affiliation
Department of Metabolism and Biotransformations, AMRI, Albany, NY 12212, USA. joseph.rich@ars.usda.gov
pubmed:publicationType
Journal Article