Linked Life Data

19390905

Source:http://linkedlifedata.com/resource/pubmed/id/19390905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-6-4
pubmed:abstractText
Since low-dose antibiotic-loaded bone cement (ALBC) was approved by the FDA for second-stage reimplantation after infected arthroplasties in 2003, commercially premixed low-dose ALBC has become available in the United States. However, surgeons continue to mix ALBC by hand. We presumed hand-mixed ALBC was not as homogeneous as commercially premixed ALBC. We assessed homogeneity by determining the variation in antibiotic elution by location in a batch, from premixed and hand-mixed formulations of low-dose ALBC. Four hand-mixed methodologies were used: (1) suspension--antibiotic powder in the liquid monomer; (2) no-mix--antibiotic powder added but not mixed with the polymer powder before adding monomer; (3) hand-stirred--antibiotic powder stirred into the polymer powder before the monomer was added; and (4) bowl-mix--antibiotic powder mixed into polymer powder using a commercial mixing bowl before the monomer was added. Antibiotic elution was measured using the Kirby-Bauer bioassay. None of the mixing methods had consistently dissimilar homogeneity of antibiotic distribution from the others. Based upon our data we conclude hand-mixed low-dose ALBC is not less homogeneous than commercially premixed formulations.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1528-1132
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
467
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1693-8
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Hand-mixed and premixed antibiotic-loaded bone cement have similar homogeneity.
pubmed:affiliation
Arizona State University, Phoenix, AZ, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't