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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-6-8
pubmed:abstractText
The present study aimed to describe the distribution and features of the SYT-SSX fusion gene in Chinese patients with synovial sarcoma (SS), and to analyze the prognostic value of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in SS. SYT-SSX1 and SYT-SSX2 fusion transcripts were tested by reverse transcription-polymerase chain reaction in 141 formalin-fixed, paraffin-embedded SS. The prognostic implication of SYT-SSX fusion type and clinicopathological parameters were analyzed by univariate and multivariate survival analyses. SYT-SSX1 and SYT-SSX2 were detected in 50 (34.5%) and 91 (64.5%) tumors, respectively. SYT-SSX1 (risk ratio [RR] = 2.032, P = 0.004), larger tumor size (RR = 1.859, P = 0.008), and aggressive Fédération Nationale des Centers de Lutte Contre le Cancer grade (RR = 2.094, P = 0.001) were adverse predictors for disease-specific survival. However, SYT-SSX fusion type was not associated with local recurrence-free survival (P = 0.216). Patients with larger tumors (RR = 2.071, P = 0.005) and those who received marginal excision (RR = 2.556, P = 0.005) had poor local recurrence-free survival. Besides, SYT-SSX1 (RR = 1.859, P = 0.037), older age (RR = 1.799, P = 0.040), and aggressive International Union Against Cancer stage (RR = 3.690, P < 0.001) proved to be adverse prognostic factors for metastasis-free survival. In conclusion, compared to SYT-SSX1, SYT-SSX2 was more frequent in Chinese patients with SS. Moreover, SYT-SSX1 was an adverse predictor for disease-specific survival and metastasis-free survival, but had no relation to local recurrence-free survival. In addition, histological grade and tumor size were also important prognostic factors for SS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1349-7006
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1018-25
pubmed:meshHeading
pubmed-meshheading:19385976-Adult, pubmed-meshheading:19385976-Antineoplastic Agents, pubmed-meshheading:19385976-China, pubmed-meshheading:19385976-DNA Primers, pubmed-meshheading:19385976-Disease-Free Survival, pubmed-meshheading:19385976-Female, pubmed-meshheading:19385976-Humans, pubmed-meshheading:19385976-Male, pubmed-meshheading:19385976-Multivariate Analysis, pubmed-meshheading:19385976-Neoplasm Metastasis, pubmed-meshheading:19385976-Neoplasm Staging, pubmed-meshheading:19385976-Odds Ratio, pubmed-meshheading:19385976-Oncogene Proteins, Fusion, pubmed-meshheading:19385976-Predictive Value of Tests, pubmed-meshheading:19385976-Prognosis, pubmed-meshheading:19385976-RNA, Neoplasm, pubmed-meshheading:19385976-Recurrence, pubmed-meshheading:19385976-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19385976-Sarcoma, Synovial
pubmed:year
2009
pubmed:articleTitle
Prognostic implication of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in synovial sarcoma.
pubmed:affiliation
Department of Pathology, Cancer Institute and Hospital, Tianjin, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't