Source:http://linkedlifedata.com/resource/pubmed/id/19385976
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2009-6-8
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pubmed:abstractText |
The present study aimed to describe the distribution and features of the SYT-SSX fusion gene in Chinese patients with synovial sarcoma (SS), and to analyze the prognostic value of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in SS. SYT-SSX1 and SYT-SSX2 fusion transcripts were tested by reverse transcription-polymerase chain reaction in 141 formalin-fixed, paraffin-embedded SS. The prognostic implication of SYT-SSX fusion type and clinicopathological parameters were analyzed by univariate and multivariate survival analyses. SYT-SSX1 and SYT-SSX2 were detected in 50 (34.5%) and 91 (64.5%) tumors, respectively. SYT-SSX1 (risk ratio [RR] = 2.032, P = 0.004), larger tumor size (RR = 1.859, P = 0.008), and aggressive Fédération Nationale des Centers de Lutte Contre le Cancer grade (RR = 2.094, P = 0.001) were adverse predictors for disease-specific survival. However, SYT-SSX fusion type was not associated with local recurrence-free survival (P = 0.216). Patients with larger tumors (RR = 2.071, P = 0.005) and those who received marginal excision (RR = 2.556, P = 0.005) had poor local recurrence-free survival. Besides, SYT-SSX1 (RR = 1.859, P = 0.037), older age (RR = 1.799, P = 0.040), and aggressive International Union Against Cancer stage (RR = 3.690, P < 0.001) proved to be adverse prognostic factors for metastasis-free survival. In conclusion, compared to SYT-SSX1, SYT-SSX2 was more frequent in Chinese patients with SS. Moreover, SYT-SSX1 was an adverse predictor for disease-specific survival and metastasis-free survival, but had no relation to local recurrence-free survival. In addition, histological grade and tumor size were also important prognostic factors for SS.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/SYT-SSX fusion protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1349-7006
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1018-25
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pubmed:meshHeading |
pubmed-meshheading:19385976-Adult,
pubmed-meshheading:19385976-Antineoplastic Agents,
pubmed-meshheading:19385976-China,
pubmed-meshheading:19385976-DNA Primers,
pubmed-meshheading:19385976-Disease-Free Survival,
pubmed-meshheading:19385976-Female,
pubmed-meshheading:19385976-Humans,
pubmed-meshheading:19385976-Male,
pubmed-meshheading:19385976-Multivariate Analysis,
pubmed-meshheading:19385976-Neoplasm Metastasis,
pubmed-meshheading:19385976-Neoplasm Staging,
pubmed-meshheading:19385976-Odds Ratio,
pubmed-meshheading:19385976-Oncogene Proteins, Fusion,
pubmed-meshheading:19385976-Predictive Value of Tests,
pubmed-meshheading:19385976-Prognosis,
pubmed-meshheading:19385976-RNA, Neoplasm,
pubmed-meshheading:19385976-Recurrence,
pubmed-meshheading:19385976-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19385976-Sarcoma, Synovial
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pubmed:year |
2009
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pubmed:articleTitle |
Prognostic implication of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in synovial sarcoma.
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pubmed:affiliation |
Department of Pathology, Cancer Institute and Hospital, Tianjin, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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