Linked Life Data

19385090

Source:http://linkedlifedata.com/resource/pubmed/id/19385090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-4-21
pubmed:abstractText
Thioredoxin 1 (Trx 1) is a redox-active small protein ubiquitously present in human body. It is one of the defensive proteins induced in response to various stress conditions. In addition to its anti-oxidative effect by dithiol-disulfide exchange in its active site, Trx 1 has anti-apoptotic and anti-inflammatory effects. Trx 1 overexpression has been shown to be effective in a wide variety of animal models for oxidative and inflammatory disorders. An administration of recombinant Trx 1 protein is also effective in animal models especially for severe acute lung diseases where Trx 1 is likely to act with its anti-inflammatory properties. Trx 1 in circulation shows anti-chemotactic effects for neutrophils and inhibitory effects against macrophage migration inhibitory factor (MIF). Neovascularization is also suppressed by Trx 1 via inhibition of the complement activation. Here we discuss precise mechanisms of Trx 1 and potential therapeutic approach of this molecule.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1872-8294
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Thioredoxin 1 delivery as new therapeutics.
pubmed:affiliation
Department of Preventive Medicine, The Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan. hj-nakamura@kitano-hp.or.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't