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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-5-18
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pubmed:abstractText |
Hemoglobin-based oxygen carriers (HBOC) of several types scavenge nitric oxide from the vasculature resulting in vasoconstriction and hypertension, both systemic and pulmonary. Phosphodiesterase-5 (PDE5) inhibitors promote nitric oxide activity and enhance vasodilation. The purpose of this study was to determine whether combined therapy of glutaraldehyde-polymerized bovine hemoglobin (HBOC) with a PDE5 inhibitor would counter the negative hemodynamic consequences of HBOC therapy alone, resulting in improved hemodynamics and oxygen delivery.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Substitutes,
http://linkedlifedata.com/resource/pubmed/chemical/Glutaral,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase 5 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/polymerized bovine hemoglobin,
http://linkedlifedata.com/resource/pubmed/chemical/sildenafil
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1530-0293
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1988-93
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19384199-Animals,
pubmed-meshheading:19384199-Blood Substitutes,
pubmed-meshheading:19384199-Glutaral,
pubmed-meshheading:19384199-Hemoglobins,
pubmed-meshheading:19384199-Male,
pubmed-meshheading:19384199-Phosphodiesterase 5 Inhibitors,
pubmed-meshheading:19384199-Phosphodiesterase Inhibitors,
pubmed-meshheading:19384199-Piperazines,
pubmed-meshheading:19384199-Polymers,
pubmed-meshheading:19384199-Purines,
pubmed-meshheading:19384199-Rats,
pubmed-meshheading:19384199-Rats, Sprague-Dawley,
pubmed-meshheading:19384199-Sulfones,
pubmed-meshheading:19384199-Vasodilator Agents
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pubmed:year |
2009
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pubmed:articleTitle |
Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition.
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pubmed:affiliation |
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA. robert.gotshall@colostate.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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