Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-4-22
pubmed:abstractText
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1878-0261
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
356-67
pubmed:meshHeading
pubmed-meshheading:19383357-Animals, pubmed-meshheading:19383357-Carrier Proteins, pubmed-meshheading:19383357-Cell Cycle, pubmed-meshheading:19383357-Cell Proliferation, pubmed-meshheading:19383357-Cell Transformation, Neoplastic, pubmed-meshheading:19383357-Embryonic Development, pubmed-meshheading:19383357-Genes, Essential, pubmed-meshheading:19383357-Hematopoietic Stem Cells, pubmed-meshheading:19383357-Humans, pubmed-meshheading:19383357-Leukemia, pubmed-meshheading:19383357-Mice, pubmed-meshheading:19383357-Monomeric Clathrin Assembly Proteins, pubmed-meshheading:19383357-Neoplasm Proteins, pubmed-meshheading:19383357-Nuclear Proteins, pubmed-meshheading:19383357-Oncogene Proteins, Fusion, pubmed-meshheading:19383357-RNA, Neoplasm, pubmed-meshheading:19383357-Tumor Markers, Biological
pubmed:year
2008
pubmed:articleTitle
The CALM and CALM/AF10 interactor CATS is a marker for proliferation.
pubmed:affiliation
Department of Medicine III, University of Munich Hospital Grosshadern, German Research Center for Environmental Health, Munich, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't