Source:http://linkedlifedata.com/resource/pubmed/id/19380819
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2009-4-21
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| pubmed:abstractText |
In human T-lymphotropic virus type 1 (HTLV-1) infection, a high frequency of HTLV-1-specific CTLs can co-exist stably with a high proviral load and the proviral load is strongly correlated with the risk of HTLV-1-associated inflammatory diseases. These observations led to the hypothesis that HTLV-1 specific CTLs are ineffective in controlling HTLV-1 replication but contribute to the pathogenesis of the inflammatory diseases. But evidence from host and viral immunogenetics and gene expression microarrays suggests that a strong CTL response is associated with a low proviral load and a low risk of HAM/TSP. Here, we quantified the frequency, lytic activity and functional avidity of HTLV-1-specific CD8(+) cells in fresh, unstimulated PBMCs from individuals with natural HTLV-1 infection. The lytic efficiency of the CD8(+) T cell response-the fraction of autologous HTLV-1-expressing cells eliminated per CD8(+) cell per day-was inversely correlated with both the proviral load and the rate of spontaneous proviral expression. The functional avidity of HTLV-1-specific CD8(+) cells was strongly correlated with their lytic efficiency. We conclude that efficient control of HTLV-1 in vivo depends on the CTL lytic efficiency, which depends in turn on CTL avidity of Ag recognition. CTL quality determines the position of virus-host equilibrium in persistent HTLV-1 infection.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
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| pubmed:volume |
182
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
5723-9
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| pubmed:meshHeading |
pubmed-meshheading:19380819-Animals,
pubmed-meshheading:19380819-Antigen Presentation,
pubmed-meshheading:19380819-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19380819-Cell Adhesion,
pubmed-meshheading:19380819-Cell Line,
pubmed-meshheading:19380819-Cell Line, Tumor,
pubmed-meshheading:19380819-Cells, Cultured,
pubmed-meshheading:19380819-Chronic Disease,
pubmed-meshheading:19380819-Cytotoxicity, Immunologic,
pubmed-meshheading:19380819-Epitopes, T-Lymphocyte,
pubmed-meshheading:19380819-Gene Products, tax,
pubmed-meshheading:19380819-Human T-lymphotropic virus 1,
pubmed-meshheading:19380819-Humans,
pubmed-meshheading:19380819-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:19380819-Paraparesis, Tropical Spastic,
pubmed-meshheading:19380819-Proviruses,
pubmed-meshheading:19380819-Rats,
pubmed-meshheading:19380819-Viral Load
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
The avidity and lytic efficiency of the CTL response to HTLV-1.
|
| pubmed:affiliation |
Department of Immunology, Wright-Fleming Institute, Imperial College London, United Kingdom.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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