| pubmed-article:19380779 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19380779 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:19380779 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19380779 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:19380779 | lifeskim:mentions | umls-concept:C1823491 | lld:lifeskim |
| pubmed-article:19380779 | lifeskim:mentions | umls-concept:C1843476 | lld:lifeskim |
| pubmed-article:19380779 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:19380779 | pubmed:dateCreated | 2009-4-21 | lld:pubmed |
| pubmed-article:19380779 | pubmed:abstractText | LPS is a natural adjuvant that potentiates Ag-specific T cell survival and Th1 differentiation by stimulating MyD88 and Toll/IL-1R domain-containing adaptor-inducing IFN-beta (TRIF) signaling pathways. In this study, we reveal the TRIF pathway is critical for amplifying murine effector T cell accumulation into nonlymphoid tissues following immunization with Ag plus LPS. Although LPS increased the accumulation of splenic T cells in TRIF-deficient mice, markedly fewer T cells were recovered from liver and lung in comparison to wild type. Most of the T cells primed in TRIF-deficient mice failed to up-regulate CXCR3 and had an overall reduced capacity to produce IFN-gamma, demonstrating effector T cell differentiation was linked to their migration. To investigate the role of TRIF-dependent cytokines, neutralization studies were performed in wild type mice. Although TNF neutralization reduced T cell numbers, its coneutralization with IL-10 unexpectedly restored the T cells, suggesting the balance between pro- and anti-inflammatory cytokines influences T cell survival rather than their magnitude. To investigate a role for costimulatory molecules, we tested whether the T cell defect in TRIF-deficient mice could be corrected with enforced costimulation. Boosting with a CD40 agonist in addition to LPS restored the effector CD8 T cell response in livers of TRIF-deficient mice while only partially restoring CD4 T cells, suggesting that LPS primes CD8 and CD4 T cell immunity through different mechanisms. Overall, our data support targeting TRIF for vaccines aimed to direct immune responses to nonlymphoid tissues. | lld:pubmed |
| pubmed-article:19380779 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19380779 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19380779 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19380779 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19380779 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19380779 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19380779 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19380779 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19380779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19380779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19380779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19380779 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19380779 | pubmed:month | May | lld:pubmed |
| pubmed-article:19380779 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19380779 | pubmed:author | pubmed-author:VellaAnthony... | lld:pubmed |
| pubmed-article:19380779 | pubmed:author | pubmed-author:RossiRobert... | lld:pubmed |
| pubmed-article:19380779 | pubmed:author | pubmed-author:McAleerJeremy... | lld:pubmed |
| pubmed-article:19380779 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19380779 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19380779 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:19380779 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19380779 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19380779 | pubmed:pagination | 5322-30 | lld:pubmed |
| pubmed-article:19380779 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:19380779 | pubmed:meshHeading | pubmed-meshheading:19380779... | lld:pubmed |
| pubmed-article:19380779 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19380779 | pubmed:articleTitle | Lipopolysaccharide potentiates effector T cell accumulation into nonlymphoid tissues through TRIF. | lld:pubmed |
| pubmed-article:19380779 | pubmed:affiliation | Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA. | lld:pubmed |
| pubmed-article:19380779 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19380779 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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