Linked Life Data

19379790

Source:http://linkedlifedata.com/resource/pubmed/id/19379790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-5-18
pubmed:abstractText
Nogo-A is an inhibitor of neurite outgrowth and axonal regeneration after CNS injury. Several functional regions including Nogo-66 were identified to mediate the inhibitory effect of Nogo-A. We have reported that Nogo-66 could promote neural progenitors to differentiate into glial cells. Here we exam three other regions of Nogo-A and show two of them also mediate the differentiation of neural progenitors. A 172-residues N-terminal region and a 37-residues C-terminal region of Nogo-A both could inhibit neuronal differentiation and promoted glial cell formation. This study illustrated that Nogo-A had multiple functional domains on the behavior of neuronal cells. The inhibitory effect of neural differentiation of Nogo-A may also contribute to its restraint of CNS repair.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1872-7972
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
458
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
132-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Effect of different regions of Nogo-A on the differentiation of neural progenitors.
pubmed:affiliation
Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing 100190, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't