Linked Life Data

19378203

Source:http://linkedlifedata.com/resource/pubmed/id/19378203

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-4-20
pubmed:abstractText
Leukodystrophies represent a wide variety of hereditary disorders of the white matter in the central nervous system, where the patients, mostly in infancy or childhood, suffer from progressive and often fatal neurological symptoms due to either a delay or lack of myelin development or loss of myelin. As only supportive therapies are available for the majority of the leukodystrophies, replacing genetically defective oligodendrocytes with intact oligodendrocytes by transplantation has a potential as a curative therapy. Animal models of leukodystrophies have been valuable in developing effective strategies of myelin repair in human diseases. This chapter discusses the animal models of leukodystrophies and describes methods for (a) derivation of mouse oligodendrocyte progenitor cells (OPCs) in vitro as a source of donor myelin-forming cells and (b) transplantation of OPCs into the brain and spinal cord of mouse models of leukodystrophies.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1064-3745
pubmed:author
pubmed:issnType
Print
pubmed:volume
549
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-85
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Transplantation of oligodendrocyte progenitor cells in animal models of leukodystrophies.
pubmed:affiliation
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural