Linked Life Data

19377983

Source:http://linkedlifedata.com/resource/pubmed/id/19377983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-4-20
pubmed:abstractText
An efficient cellular drug delivery is a severe problem due to the charge, the hydrophilic character or the size of many therapeutic agents. High-drug doses, necessary to compensate the reduced bioavailability, often cause strong adverse effects. Synthetic drug delivery vectors will solve this problem, if limitations like low-cellular uptake efficiency or cytotoxicity can be overcome. Among these synthetic vectors, so-called cell-penetrating peptides (CPP) have proven their applicability as drug carriers. The ability to penetrate cellular membranes without the help of any receptor or transporter molecule was also found for derivatives of the native peptide hormone human calcitonin (hCT). We have shown that truncated hCT analogs with a branched peptide design and oligocationic side chain sequences - hCT(18-32)-k 7 and hCT(9-32)-2 br - are very interesting candidates as carrier peptides for drug delivery. Both peptides were found to efficiently shuttle covalently linked small molecules and non-covalently complexed DNA and RNA inside human embryonic kidney cells (HEK 293).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1064-3745
pubmed:author
pubmed:issnType
Print
pubmed:volume
535
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-403
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Synthesis and application of peptides as drug carriers.
pubmed:affiliation
Leipzig University, Leipzig, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't