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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-6
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pubmed:abstractText |
High mobility group (HMG) proteins regulate chromatin architecture and gene expression. Constitutional rearrangement of an HMG family member, HMGA2, in an 8-year old boy resulted in extreme overgrowth and advanced bone development. Moreover, a recent genome-wide association study documented an association between a variant in the 3' untranslated region of HMGA2 (rs1042725) and height in otherwise healthy individuals. We attempted to extend these findings by testing if this HMGA2 polymorphism is associated with other skeletal measures in two large population cohorts of diverse race/ethnicity. Genotyping was completed in 1680 Afro-Caribbean men aged > or = 40 years and 1548 Caucasian American men aged > or = 69 years. Bone mineral density (BMD) was assessed with peripheral quantitative computed tomography. The minor allele frequency of rs1042725 was 32% among Afro-Caribbeans and 48% among Caucasians (p<0.0001). No association was observed with height in either study cohort. However, presence of the minor allele of this SNP was associated with decreased tibia trabecular volumetric BMD in both populations (p=0.007 Afro-Caribbean; p=0.0007 Caucasian). Real-time quantitative RT-PCR and Western blot analysis demonstrated HMGA2 mRNA and protein expression in the human fetal osteoblast cell line, hFOB. Our analyses suggest a novel association between a common genetic variant in HMGA2 and trabecular BMD in ethnically diverse older men. Additional research is needed to better understand the role of HMGA2 in the regulation of bone metabolism.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/R01 AR049747-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AR051124-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA084950-01,
http://linkedlifedata.com/resource/pubmed/grant/R01-AR049747,
http://linkedlifedata.com/resource/pubmed/grant/R01-AR051124,
http://linkedlifedata.com/resource/pubmed/grant/R01-CA84950,
http://linkedlifedata.com/resource/pubmed/grant/U01 AG018197-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 AG027810-01A1,
http://linkedlifedata.com/resource/pubmed/grant/U01 AG18197,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR045580-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR045583-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR045614-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR045632-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR045647-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR045654-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR45580,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR45583,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR45614,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR45632,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR45647,
http://linkedlifedata.com/resource/pubmed/grant/U01 AR45654,
http://linkedlifedata.com/resource/pubmed/grant/U01-AG027810,
http://linkedlifedata.com/resource/pubmed/grant/UL1 RR024140,
http://linkedlifedata.com/resource/pubmed/grant/UL1 RR024140-01
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-10398424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-10519386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-11494149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-11602345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-12693954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-15593017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-16084776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-16085466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-16375854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-16807757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-16831886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-16901784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-17437991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-17767157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-17874032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-18193045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-18391952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-2688394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-9659816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-9703685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19376282-9722980
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1873-2763
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pubmed:author |
pubmed-author:BunkerClareann HCH,
pubmed-author:CauleyJane AJA,
pubmed-author:ChuYanxiaY,
pubmed-author:HoffmanAndrew RAR,
pubmed-author:KuipersAllisonA,
pubmed-author:NestlerodeCara SCS,
pubmed-author:OrwollEric SES,
pubmed-author:PatrickAlan LAL,
pubmed-author:WheelerVictor WVW,
pubmed-author:ZhangYingzeY,
pubmed-author:ZmudaJoseph MJM
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
295-300
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19376282-Humans,
pubmed-meshheading:19376282-European Continental Ancestry Group,
pubmed-meshheading:19376282-Caribbean Region,
pubmed-meshheading:19376282-Bone and Bones,
pubmed-meshheading:19376282-Aged,
pubmed-meshheading:19376282-Aged, 80 and over,
pubmed-meshheading:19376282-African Continental Ancestry Group,
pubmed-meshheading:19376282-Anthropometry,
pubmed-meshheading:19376282-Male,
pubmed-meshheading:19376282-Adult,
pubmed-meshheading:19376282-Osteoblasts,
pubmed-meshheading:19376282-Middle Aged,
pubmed-meshheading:19376282-RNA, Messenger,
pubmed-meshheading:19376282-Cell Line,
pubmed-meshheading:19376282-Bone Density,
pubmed-meshheading:19376282-Protein Isoforms,
pubmed-meshheading:19376282-Gene Expression Regulation,
pubmed-meshheading:19376282-HMGA2 Protein
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