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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-6-1
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pubmed:abstractText |
Kaempferol 3-neohesperidoside is one of the several compounds that have been reported to have insulin-like properties in terms of glucose lowering. We studied the effect of kaempferol 3-neohesperidoside in glycogen synthesis in rat soleus muscle through the incorporation of (14)C-d-glucose in glycogen. Kaempferol 3-neohesperidoside stimulates glycogen synthesis in rat soleus muscle by approximately 2.38-fold. Insulin at 100 nM showed a stimulatory effect on glycogen synthesis when compared with the control group. The stimulatory effect of kaempferol 3-neophesperidoside on glycogen synthesis was inhibited by wortmannin, the phosphatidylinositol 3-kinase (PI3K) inhibitor, and enhanced by lithium chloride, a glycogen synthase kinase 3 (GSK-3) inhibitor. Moreover, the stimulatory effect of kaempferol 3-neohesperidoside was also nullified by PD98059, a specific inhibitor of mitogen-activated protein kinase (MEK) and by calyculin A, an inhibitor of protein phosphatase 1 (PP1) activity. It was concluded that the PI3K - GSK-3 pathway and MAPK - PP1 pathway are involved in the stimulatory kaempferol 3-neohesperidoside effect on glycogen synthesis in rat soleus muscle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Androstadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Kaempferols,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Phosphatase 1,
http://linkedlifedata.com/resource/pubmed/chemical/calyculin A,
http://linkedlifedata.com/resource/pubmed/chemical/kaempferol 3-O-neohesperidoside,
http://linkedlifedata.com/resource/pubmed/chemical/wortmannin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1638-6183
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
843-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19376191-Adjuvants, Immunologic,
pubmed-meshheading:19376191-Androstadienes,
pubmed-meshheading:19376191-Animals,
pubmed-meshheading:19376191-Enzyme Inhibitors,
pubmed-meshheading:19376191-Flavonoids,
pubmed-meshheading:19376191-Glycogen,
pubmed-meshheading:19376191-Glycogen Synthase Kinase 3,
pubmed-meshheading:19376191-Hypoglycemic Agents,
pubmed-meshheading:19376191-Insulin,
pubmed-meshheading:19376191-Insulin Antagonists,
pubmed-meshheading:19376191-Kaempferols,
pubmed-meshheading:19376191-Lithium Chloride,
pubmed-meshheading:19376191-Male,
pubmed-meshheading:19376191-Mitogen-Activated Protein Kinases,
pubmed-meshheading:19376191-Muscle, Skeletal,
pubmed-meshheading:19376191-Oxazoles,
pubmed-meshheading:19376191-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:19376191-Protein Phosphatase 1,
pubmed-meshheading:19376191-Rats,
pubmed-meshheading:19376191-Rats, Wistar,
pubmed-meshheading:19376191-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle.
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pubmed:affiliation |
Departamento de Bioquímica, Centro de Ciências Biológicas, UFSC, Campus Universitário, Bairro Trindade. Cx. Postal 5069, CEP: 88040-970 - Florianópolis, SC, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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