Linked Life Data

19375242

Source:http://linkedlifedata.com/resource/pubmed/id/19375242

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-5-27
pubmed:abstractText
Estrogens are suggested to play an important role in the development of osteoarthritis (OA). Though many clinical and experimental researches have been carried out to investigate the relationship between OA and circulating estrogen or exogenous estrogen, the discrepancy among the results of these studies was also too large to get reconcilable conclusion. In the past several years, locally synthesized estrogens have been found and proved to contribute significantly to the turnover and function of bone tissues independent of circulating estrogen concentrations. We hypothesize that estrogens synthesized locally in bone or synovial tissues have a profound effect on the development OA. Future investigation of local estrogen in bone tissues may give, at least partially, valuable evidences for the etiology and treatment strategy of OA. In our opinion, regulating the amount and effect of locally synthesized estrogen may hold intriguing prospects for the treatment of OA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1532-2777
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
144-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Locally synthesized estrogen: a novel target in the development of OA.
pubmed:affiliation
School of Stomatology, The Fourth Military Medical University, No. 145 West ChangLe Road, Xi'an 710032, PR China.
pubmed:publicationType
Journal Article