Source:http://linkedlifedata.com/resource/pubmed/id/19374435
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2010-6-21
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pubmed:abstractText |
Three new norsesquiterpenoid glycosides, 4'-hydroxyphyllaemblicin B (1) and phyllaemblicins E (2) and F (3), were isolated from the roots of Phyllanthus emblica, together with three known compounds, phyllaemblic acid (4), phyllaemblicin B (5), and phyllaemblicin C (6). Of these, 3 is a new norsesquiterpenoid dimer. The structures of 1-3 were established by spectroscopic data information and by acidic hydrolysis. The isolated compounds, together with two other known analogues, phyllaemblic acid methyl ester (7) and phyllaemblicin A (8), were evaluated for their antiviral activity toward coxsackie virus B3 (CVB3) by an in vitro cytopathic effect inhibitory assay. Compounds 5-7 exhibited strong anti-CVB3 activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1520-6025
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
969-72
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pubmed:meshHeading |
pubmed-meshheading:19374435-Antiviral Agents,
pubmed-meshheading:19374435-Drugs, Chinese Herbal,
pubmed-meshheading:19374435-Enterovirus B, Human,
pubmed-meshheading:19374435-Glycosides,
pubmed-meshheading:19374435-HeLa Cells,
pubmed-meshheading:19374435-Humans,
pubmed-meshheading:19374435-Molecular Structure,
pubmed-meshheading:19374435-Phyllanthus emblica,
pubmed-meshheading:19374435-Plant Roots,
pubmed-meshheading:19374435-Sesquiterpenes
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pubmed:year |
2009
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pubmed:articleTitle |
Anti-coxsackie virus B3 norsesquiterpenoids from the roots of Phyllanthus emblica.
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pubmed:affiliation |
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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