Linked Life Data

19374194

Source:http://linkedlifedata.com/resource/pubmed/id/19374194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-4-20
pubmed:abstractText
Papillomavirus is a pathogenic virus that induces benign tumor at the infected lesion, and its association with malignant tumor was first identified by R. Shope using animal model. A variety of cancers have been reported to be associated with the infection of human papillomavirus since the report by H. zur Hausen that describes a connection between the HPV infection and cervical cancer. The HPV infection is broadly distributed as a sexually transmitted disease (STD) and recently the initial age diagnosed as the cervical cancer is getting lowered. Because of its clinical importance, the study on HPV has been focused on the oncogenic properties, and the results of which had great impacts on the researches of the tumor suppressors, such as p53 and pRb, and "ubiquiitn-proteasome" pathway. On the other hand, the biological properties of HPV remain mostly disclosed. The lifecycle of HPV is tightly linked to the differentiation program of the target epithelial cell, and this unique property has hampered the study on the HPV replication mechanism. Here we summarized the findings on the HPV lifecycle, including the virus gene functions, the regulation of viral gene expression and replication.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0042-6857
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-72
pubmed:dateRevised
2011-2-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[Life cycle of HPV governed by the differentiation program of epithelial cell].
pubmed:affiliation
Lab. Gene Anal., Dept. Viral Oncol., Inst. Virus Res., Kyoto Univ., Sakyo-ku, Kyoto 606-8507, Japan. asatsuka@virus.kyoto-u.ac.jp
pubmed:publicationType
Journal Article, English Abstract, Review