Linked Life Data

19373977

Source:http://linkedlifedata.com/resource/pubmed/id/19373977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-4-16
pubmed:abstractText
The purpose of this study was to investigate the effect of antioxidant ingestion on stress-induced impairment of cognitive memory. Male C57BL/6 mice were divided into four groups as follows: (1) control mice (C mice) fed in a normal cage without immobilization; (2) restraint-stressed (RS mice) fed in a small cage; (3) vitamin E mice (VE mice), mice were fed in a small cage with a diet supplemented with vitamin E; (4) GliSODin mice (GS mice) fed in a small cage with a diet supplemented with GliSODin. RS, VE and GS mice were exposed to 12 h of immobilization daily. Five weeks later, spatial learning was measured using the Morris Water Maze (MWM) test. After water maze testing, we performed immunohistochemical analysis using 4-hydroxy-2-noneral (4-HNE) and an anti-Ki67 antibody. 4-HNE is a marker of lipid peroxidation. RS mice showed impaired spatial learning performance and an increased number of 4-HNE-positive cells in the granule cell layer (GCL) of the hippocampal dentate gyrus when compared to C mice. Moreover, RS mice showed a decreased number of Ki67-positive cells in the subgranular zone (SGZ). GS mice showed better spatial learning memory than RS mice. The number of 4-HNE-positive cells in the GCL of GS mice was significantly less than that of RS mice. The number of Ki67-positive cells in the SGZ of GS mice was significantly greater than that of RS mice. These finding suggests that GliSODin prevents stress-induced impairment of cognitive function and maintains neurogenesis in the hippocampus through antioxidant activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1872-7549
pubmed:author
pubmed:issnType
Electronic
pubmed:day
8
pubmed:volume
200
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-21
pubmed:meshHeading
pubmed-meshheading:19373977-Administration, Oral, pubmed-meshheading:19373977-Aldehydes, pubmed-meshheading:19373977-Animals, pubmed-meshheading:19373977-Antioxidants, pubmed-meshheading:19373977-Cucurbitaceae, pubmed-meshheading:19373977-Hippocampus, pubmed-meshheading:19373977-Ki-67 Antigen, pubmed-meshheading:19373977-Male, pubmed-meshheading:19373977-Maze Learning, pubmed-meshheading:19373977-Memory Disorders, pubmed-meshheading:19373977-Mice, pubmed-meshheading:19373977-Mice, Inbred C57BL, pubmed-meshheading:19373977-Neurogenesis, pubmed-meshheading:19373977-Neurons, pubmed-meshheading:19373977-Nutritional Support, pubmed-meshheading:19373977-Reaction Time, pubmed-meshheading:19373977-Restraint, Physical, pubmed-meshheading:19373977-Stress, Psychological, pubmed-meshheading:19373977-Superoxide Dismutase, pubmed-meshheading:19373977-Tocopherols
pubmed:year
2009
pubmed:articleTitle
Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory.
pubmed:affiliation
Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Kanagawa 211-8533, Japan.
pubmed:publicationType
Journal Article