Although the use of HIV protease inhibitors is linked to the development of insulin resistance and other metabolic changes that greatly increase the risk for cardiovascular disease, the molecular mechanisms responsible remain incompletely understood. This review summarizes recent advances that have been made in understanding the relative contributions of individual protease inhibitors to both acute and chronic insulin resistance together with newly identified cellular mediators.
Department of Pediatrics, USA Department of Cellular Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA. hruz_p@kids.wustl.edu
