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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-30
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pubmed:abstractText |
It has been demonstrated in vitro that the dopamine D(2) receptor has 2 interconvertible affinity states for endogenous dopamine, referred to as the high- and the low-affinity states. (11)C-(R)-2-CH(3)O-N-n-propylnorapomorphine ((11)C-MNPA) is a new agonist radioligand for in vivo imaging of the high-affinity state of dopamine D(2) receptors using PET. In the present study, the kinetics of (11)C-MNPA were examined for the first time, to our knowledge, in the human brain and analyzed using quantitative approaches with or without an arterial input function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0161-5505
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pubmed:author |
pubmed-author:ArakawaRyosukeR,
pubmed-author:FardeLarsL,
pubmed-author:FinnemaSjoerdS,
pubmed-author:HalldinChristerC,
pubmed-author:HirayasuYoshioY,
pubmed-author:ItoHiroshiH,
pubmed-author:KodakaFumitoshiF,
pubmed-author:MiyoshiMichieM,
pubmed-author:NakaoRyujiR,
pubmed-author:OkumuraMasakiM,
pubmed-author:OtsukaTatsuiT,
pubmed-author:SekiChieC,
pubmed-author:SekineMizuhoM,
pubmed-author:SuharaTetsuyaT,
pubmed-author:SuzukiKazutoshiK,
pubmed-author:TakahashiHidehikoH,
pubmed-author:TakanoHarumasaH
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
703-10
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pubmed:meshHeading |
pubmed-meshheading:19372485-Adult,
pubmed-meshheading:19372485-Apomorphine,
pubmed-meshheading:19372485-Brain,
pubmed-meshheading:19372485-Humans,
pubmed-meshheading:19372485-Image Interpretation, Computer-Assisted,
pubmed-meshheading:19372485-Male,
pubmed-meshheading:19372485-Metabolic Clearance Rate,
pubmed-meshheading:19372485-Positron-Emission Tomography,
pubmed-meshheading:19372485-Radiopharmaceuticals,
pubmed-meshheading:19372485-Receptors, Dopamine D2,
pubmed-meshheading:19372485-Tissue Distribution,
pubmed-meshheading:19372485-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-N-n-propylnorapomorphine in the human brain.
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pubmed:affiliation |
Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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