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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-10-21
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pubmed:abstractText |
Five new antibacterial ambiguine K-O isonitriles (1-5) and eight previously described indole alkaloids were isolated from the cultured cyanobacterium Fischerella ambigua (UTEX 1903) by bioassay-guided fractionation. The planar structures of the new compounds were determined by spectroscopic analysis including MS and 1D and 2D NMR. X-ray crystallography was used to determine the absolute stereoconfiguration of ambiguine K isonitrile. The isolates were evaluated for their antibacterial activities against a set of bacterial targets, including Mycobacterium tuberculosis and Bacillus anthracis. Ambiguine K and M isonitriles showed the most potent activity against M. tuberculosis, with MIC values of 6.6 and 7.5 microM, respectively. Ambiguine A isonitrile showed the most potent activity against B. anthracis, with a MIC of 1.0 microM.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-10412206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-11267769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-11277744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-11574027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-15198586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-15205405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-16262402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-16294828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-16448105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-16523402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-16884299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-17315959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-17336349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-17377577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-17975918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-18772933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-18834150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-19035635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-8988597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19371071-9145860
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1520-6025
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
894-9
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua.
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pubmed:affiliation |
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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