Source:http://linkedlifedata.com/resource/pubmed/id/19370450
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2009-11-20
|
| pubmed:abstractText |
In coeliac disease, small-bowel mucosal permeability is increased in response to gluten consumption. However, the signalling routes leading to such a barrier defect remain obscure. As the epidermal growth factor receptor (EGFR) pathway is up-regulated in untreated coeliac disease, and since this cascade has been related to epithelial hyperpermeability, the aim of this study was to establish whether blocking the EGFR route would restore the barrier after gliadin insult in vitro.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1502-7708
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
820-5
|
| pubmed:meshHeading |
pubmed-meshheading:19370450-Blotting, Western,
pubmed-meshheading:19370450-Caco-2 Cells,
pubmed-meshheading:19370450-Celiac Disease,
pubmed-meshheading:19370450-Cells, Cultured,
pubmed-meshheading:19370450-Electric Impedance,
pubmed-meshheading:19370450-Gliadin,
pubmed-meshheading:19370450-Humans,
pubmed-meshheading:19370450-Intestinal Mucosa,
pubmed-meshheading:19370450-Microscopy, Confocal,
pubmed-meshheading:19370450-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19370450-Signal Transduction,
pubmed-meshheading:19370450-Statistics, Nonparametric
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Inhibition of epithelial growth factor receptor signalling does not preserve epithelial barrier function after in vitro gliadin insult.
|
| pubmed:affiliation |
Paediatric Research Centre, Medical School, University of Tampere, Finland.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|