19370027

Source:http://linkedlifedata.com/resource/pubmed/id/19370027

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007709, umls-concept:C0242609, umls-concept:C0449829, umls-concept:C0597767, umls-concept:C1704788
pubmed:issue	7240
pubmed:dateCreated	2009-4-16
pubmed:abstractText	During cell division microtubules capture chromosomes by binding to the kinetochore assembled in the centromeric region of chromosomes. In mitosis sister chromatids are captured by microtubules emanating from both spindle poles, a process called bipolar attachment, whereas in meiosis I sisters are attached to microtubules originating from one spindle pole, called monopolar attachment. For determining chromosome orientation, kinetochore geometry or structure might be an important target of regulation. However, the molecular basis of this regulation has remained elusive. Here we show the link between kinetochore orientation and cohesion within the centromere in fission yeast Schizosaccharomyces pombe by strategies developed to visualize the concealed cohesion within the centromere, and to introduce artificial tethers that can influence kinetochore geometry. Our data imply that cohesion at the core centromere induces the mono-orientation of kinetochores whereas cohesion at the peri-centromeric region promotes bi-orientation. Our study may reveal a general mechanism for the geometric regulation of kinetochores, which collaborates with previously defined tension-dependent reorientation machinery.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0410462
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1476-4687
pubmed:author	pubmed-author:SakunoTakeshiT, pubmed-author:TadaKenjiK, pubmed-author:WatanabeYoshinoriY
pubmed:issnType	Electronic
pubmed:day	16
pubmed:volume	458
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	852-8
pubmed:meshHeading	pubmed-meshheading:19370027-Centromere, pubmed-meshheading:19370027-Chromosome Segregation, pubmed-meshheading:19370027-Kinetochores, pubmed-meshheading:19370027-Meiosis, pubmed-meshheading:19370027-Microtubules, pubmed-meshheading:19370027-Mitosis, pubmed-meshheading:19370027-Models, Biological, pubmed-meshheading:19370027-Schizosaccharomyces
pubmed:year	2009
pubmed:articleTitle	Kinetochore geometry defined by cohesion within the centromere.
pubmed:affiliation	Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't