Source:http://linkedlifedata.com/resource/pubmed/id/19369177
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2009-4-16
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pubmed:abstractText |
The Val108/158Met (rs4680) single nucleotide polymorphism (SNP) in the catechol-O-methyltransferase (COMT) gene contributes to genetic susceptibility to schizophrenia, which is specifically related to impairments in executive functioning. A different genomic region composed of three SNPs (rs737865, rs4680, rs165599) within the COMT gene has been reported to be significantly associated with schizophrenia in Ashkenazi Jews. This study aims to clarify the association between these three SNPs and their haplotypes with schizophrenia and neurocognitive functioning, using both case-control and family-based designs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0929-6646
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-9
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pubmed:meshHeading |
pubmed-meshheading:19369177-Adult,
pubmed-meshheading:19369177-Age of Onset,
pubmed-meshheading:19369177-Asian Continental Ancestry Group,
pubmed-meshheading:19369177-Case-Control Studies,
pubmed-meshheading:19369177-Catechol O-Methyltransferase,
pubmed-meshheading:19369177-Female,
pubmed-meshheading:19369177-Genetic Predisposition to Disease,
pubmed-meshheading:19369177-Genotype,
pubmed-meshheading:19369177-Humans,
pubmed-meshheading:19369177-Male,
pubmed-meshheading:19369177-Phenotype,
pubmed-meshheading:19369177-Polymorphism, Single Nucleotide,
pubmed-meshheading:19369177-Schizophrenia,
pubmed-meshheading:19369177-Taiwan,
pubmed-meshheading:19369177-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Association of the 3' region of COMT with schizophrenia in Taiwan.
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pubmed:affiliation |
Department of Psychiatry, National Taiwan University Hospital, Yun Lin Branch, Yunlin, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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