Linked Life Data

19369113

Source:http://linkedlifedata.com/resource/pubmed/id/19369113

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-5-4
pubmed:abstractText
The biosynthesis of the microbial small molecule iron scavengers known as siderophores has been of interest since their discovery in the middle of the past century. Two main pathways for siderophore biosynthesis exist. One is directed by a large family of modular multienzymes called non-ribosomal peptide synthetases (NRPSs) while the other is NRPS independent. There has been a vast increase in our knowledge of siderophore biosynthesis over the past two decades and the enzymology of several NRPS-dependent pathways is now well-understood while dramatic recent progress has also been made in elucidating NRPS-independent pathways. As siderophores are virulence factors in many pathogenic microorganisms, genetic and biochemical knowledge of siderophore biosynthetic pathways can aid in the development of new antimicrobials as well as increasing our understanding of the natural machinery for the efficient assembly of structurally complex bioactive natural products.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1879-0402
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-15
pubmed:dateRevised
2009-8-25
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Recent advances in siderophore biosynthesis.
pubmed:affiliation
Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.
pubmed:publicationType
Journal Article, Review