Linked Life Data

19368720

Source:http://linkedlifedata.com/resource/pubmed/id/19368720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-4-27
pubmed:abstractText
Interleukin-6 is a multifunctional cytokine that is critical for T/B-cell differentiation and maturation, immunoglobulin secretion, acute-phase protein production, and macrophage/monocyte functions. Extensive research into the biology of IL-6 has implicated IL-6 in the pathophysiology and pathogenesis of RA. An anti-murine IL-6 mAb that neutralizes mouse IL-6 activities was tested in animal model of collagen-induced arthritis. Prophylactic treatment with anti-IL-6 mAb significantly reduced the incidence and severity of arthritis compared to control mAb treated mice. The mitogenic response of B and T cells isolated from the lymph nodes of anti-IL-6 treated mice was significantly reduced compared to cells isolated from control mAb treated mice. The overall histopathology score for paws from the anti-IL-6 treated mice was significantly reduced when compared to paws from mice treated with control mAb, including both inflammatory (synovitis and pannus) and erosive (erosions and architecture) parameters. Reduced loss of cartilage matrix components was also observed in the anti-IL-6 treated mice. Collectively, these data suggest that IL-6 plays a major role in the pathophysiology of rheumatoid arthritis, and thus support the potential benefit of anti-IL-6 mAb treatment in rheumatoid arthritis patients.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-12165438, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-12220549, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-12370259, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-12960349, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-15314695, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-15771564, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-16899107, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-16899108, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-17708740, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-17708744, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-17978466, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-6792316, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-8474061, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-9653168, http://linkedlifedata.com/resource/pubmed/commentcorrection/19368720-9870868
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1476-9255
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10
pubmed:dateRevised
2011-9-2
pubmed:year
2009
pubmed:articleTitle
Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis.
pubmed:affiliation
Orthopaedic Research Institute, 929 North St, Francis, Wichita, Kansas 67214, USA. Paul_Wooley@via-christi.org.
pubmed:publicationType
Journal Article