Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-5-8
pubmed:abstractText
Many studies have shown that primary prostate cancers are multifocal and are composed of multiple genetically distinct cancer cell clones. Whether or not multiclonal primary prostate cancers typically give rise to multiclonal or monoclonal prostate cancer metastases is largely unknown, although studies at single chromosomal loci are consistent with the latter case. Here we show through a high-resolution genome-wide single nucleotide polymorphism and copy number survey that most, if not all, metastatic prostate cancers have monoclonal origins and maintain a unique signature copy number pattern of the parent cancer cell while also accumulating a variable number of separate subclonally sustained changes. We find no relationship between anatomic site of metastasis and genomic copy number change pattern. Taken together with past animal and cytogenetic studies of metastasis and recent single-locus genetic data in prostate and other metastatic cancers, these data indicate that despite common genomic heterogeneity in primary cancers, most metastatic cancers arise from a single precursor cancer cell. This study establishes that genomic archeology of multiple anatomically separate metastatic cancers in individuals can be used to define the salient genomic features of a parent cancer clone of proven lethal metastatic phenotype.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-10223244, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-10797498, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-11309499, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-12597930, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-1359641, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-15026333, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-15604294, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-16403791, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-16642477, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-17222606, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-17881897, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-18172304, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-18483239, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-18508478, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-18974140, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-19047148, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-20965042, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-3048652, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-3756870, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-7933231, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-8284886, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-8958808, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-9000575, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-9108466, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-9121588, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-9426051, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-9443392, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-9462681, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-959840, http://linkedlifedata.com/resource/pubmed/commentcorrection/19363497-9815901
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1546-170X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
559-65
pubmed:dateRevised
2010-10-27
pubmed:meshHeading
pubmed-meshheading:19363497-African Continental Ancestry Group, pubmed-meshheading:19363497-Animals, pubmed-meshheading:19363497-Chromosome Mapping, pubmed-meshheading:19363497-Chromosomes, Human, Pair 13, pubmed-meshheading:19363497-Chromosomes, Human, Pair 6, pubmed-meshheading:19363497-Comparative Genomic Hybridization, pubmed-meshheading:19363497-Continental Population Groups, pubmed-meshheading:19363497-DNA, Neoplasm, pubmed-meshheading:19363497-DNA Damage, pubmed-meshheading:19363497-Humans, pubmed-meshheading:19363497-Male, pubmed-meshheading:19363497-Neoplasm Metastasis, pubmed-meshheading:19363497-Neoplasm Staging, pubmed-meshheading:19363497-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:19363497-Phenotype, pubmed-meshheading:19363497-Polymorphism, Single Nucleotide, pubmed-meshheading:19363497-Prostatic Neoplasms, pubmed-meshheading:19363497-Sequence Deletion
pubmed:year
2009
pubmed:articleTitle
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer.
pubmed:publicationType
Letter, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural