Linked Life Data

19362955

Source:http://linkedlifedata.com/resource/pubmed/id/19362955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-4-13
pubmed:abstractText
Genetic polymorphisms of genes involved in DNA repair and glutathione metabolic pathways may affect patients' response to platinum-based chemotherapy. We retrospectively assessed whether single nucleotide polymorphisms (SNP) of DNA-repair genes ERCC1, XPD, XRCC1 and glutathione S-transferase genes GSTP1, GSTT1 and GSTM1 predict overall survival (OS), response and toxicity in 119 non-small-cell lung cancer (NSCLC) patients treated with platinum-based regimens as first- or second-line chemotherapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/ERCC1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/ERCC2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Endonucleases, http://linkedlifedata.com/resource/pubmed/chemical/GSTP1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione S-Transferase pi, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase, http://linkedlifedata.com/resource/pubmed/chemical/Organoplatinum Compounds, http://linkedlifedata.com/resource/pubmed/chemical/X-ray repair cross complementing..., http://linkedlifedata.com/resource/pubmed/chemical/Xeroderma Pigmentosum Group D..., http://linkedlifedata.com/resource/pubmed/chemical/glutathione S-transferase M1, http://linkedlifedata.com/resource/pubmed/chemical/glutathione S-transferase T1
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1525-7304
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-23
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19362955-Adenocarcinoma, pubmed-meshheading:19362955-Adenocarcinoma, Bronchiolo-Alveolar, pubmed-meshheading:19362955-Adult, pubmed-meshheading:19362955-Aged, pubmed-meshheading:19362955-Aged, 80 and over, pubmed-meshheading:19362955-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:19362955-Carcinoma, Squamous Cell, pubmed-meshheading:19362955-DNA Repair, pubmed-meshheading:19362955-DNA-Binding Proteins, pubmed-meshheading:19362955-Endonucleases, pubmed-meshheading:19362955-Female, pubmed-meshheading:19362955-Genotype, pubmed-meshheading:19362955-Glutathione S-Transferase pi, pubmed-meshheading:19362955-Glutathione Transferase, pubmed-meshheading:19362955-Humans, pubmed-meshheading:19362955-Lung Neoplasms, pubmed-meshheading:19362955-Male, pubmed-meshheading:19362955-Middle Aged, pubmed-meshheading:19362955-Organoplatinum Compounds, pubmed-meshheading:19362955-Polymerase Chain Reaction, pubmed-meshheading:19362955-Polymorphism, Genetic, pubmed-meshheading:19362955-Polymorphism, Restriction Fragment Length, pubmed-meshheading:19362955-Prognosis, pubmed-meshheading:19362955-Retrospective Studies, pubmed-meshheading:19362955-Survival Rate, pubmed-meshheading:19362955-Treatment Outcome, pubmed-meshheading:19362955-Xeroderma Pigmentosum Group D Protein
pubmed:year
2009
pubmed:articleTitle
DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer.
pubmed:affiliation
Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Crete, Greece.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't