rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
2009-5-4
|
pubmed:abstractText |
A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Three candidates had encouraging results for the development of new anti-SARS compounds.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3C-like protease, SARS coronavirus,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzothiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Chymases,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Ketones,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidinones,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1464-3405
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
15
|
pubmed:volume |
19
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2722-7
|
pubmed:meshHeading |
pubmed-meshheading:19362479-Amino Acid Sequence,
pubmed-meshheading:19362479-Antiviral Agents,
pubmed-meshheading:19362479-Benzothiazoles,
pubmed-meshheading:19362479-Chymases,
pubmed-meshheading:19362479-Computer Simulation,
pubmed-meshheading:19362479-Cysteine Endopeptidases,
pubmed-meshheading:19362479-Drug Design,
pubmed-meshheading:19362479-Ketones,
pubmed-meshheading:19362479-Peptides,
pubmed-meshheading:19362479-Protease Inhibitors,
pubmed-meshheading:19362479-Pyrrolidinones,
pubmed-meshheading:19362479-SARS Virus,
pubmed-meshheading:19362479-Structure-Activity Relationship,
pubmed-meshheading:19362479-Thiazoles,
pubmed-meshheading:19362479-Viral Proteins
|
pubmed:year |
2009
|
pubmed:articleTitle |
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.
|
pubmed:affiliation |
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|