Linked Life Data

1936187

Source:http://linkedlifedata.com/resource/pubmed/id/1936187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-12-11
pubmed:abstractText
Lipid and protein biosynthesis were investigated in organ culture of human lenses from subjects ranging from 8 to 95 years old. A marked increase of protein and cholesterol content of the human lens with age was found. No significant linear correlation of age with either cholesterol or fatty acid synthesis was observed. Moreover, there are no indications that either synthesis declines with increasing age of the subject. Notwithstanding the large variety in age of the subjects, cholesterol and fatty acid synthesis of the individual lenses were correlated with each other in a positive linear way. Non-cataractous lenses as old as 80 years revealed a normal protein synthesis pattern as determined by incorporation of [35S]methionine into protein and analysis by 2D-gel electrophoresis. In addition, they maintained a high protein biosynthetic capacity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
519-24
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Biosynthetic capacity of the human lens upon aging.
pubmed:affiliation
TNO Institute of Aging and Vascular Research (IVVO-TNO), Gaubius Laboratory, Leiden, The Netherlands.
pubmed:publicationType
Journal Article