Linked Life Data

1936123

Source:http://linkedlifedata.com/resource/pubmed/id/1936123

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1991-12-13
pubmed:abstractText
This study examines the effect of heat-induced stress on the function of splenic antigen-presenting cells. Heat shock (at 41 degrees C, 45 degrees C) profoundly inhibits the ability of this population to stimulate antigen-specific proliferation in ex vivo, or short-term cultures of T cells. This inhibition is not due to the release of suppressor factors from the antigen-presenting cells, nor to a lack of interleukin 1. Comparison of the effect of heat shock on presentation to a T cell hybridoma suggest that heat shock may affect the ability of antigen-presenting cells to deliver a co-stimulatory signal to the T cell. The implication of these findings in terms of the regulation of autoimmune phenomena is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2791-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Temperature-induced stress abrogates co-stimulatory function in antigen-presenting cells.
pubmed:affiliation
I.C.R.F. Tumour Immunology Unit, Department of Biology, University College, London, GB.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't