Linked Life Data

19360438

Source:http://linkedlifedata.com/resource/pubmed/id/19360438

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-4-30
pubmed:abstractText
Cell locomotion, including cancer cell invasion, is closely associated with the dynamics of cytoskeletal structures. Previous in vitro studies indicated that tubulin isotype composition may affect polymerization properties and dynamics of microtubules. Colorectal cancer is a good model for studying tumour invasion because of the easily detectable invasive front. Hence, we investigated the localization of beta(III)-tubulin in colorectal cancer specimens. Immunohistochemical staining for beta(III)-tubulin was evident in cancer cells apparently budding from adjacent malignant cells with a higher differentiation and negative staining. An association between beta(III)-tubulin immunoreactivity and tumour budding grade was demonstrated. To the best of our knowledge, this is the first report documenting a preferential localization of beta(III)-tubulin in the invading epithelium. From this finding arises the possibility that changes in tubulin isotypes could modulate the invading activity of cancer cells. Further investigations are needed to determine whether our findings have clinical implications.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0945-6317
pubmed:author
pubmed:issnType
Print
pubmed:volume
454
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
541-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
beta(III)-tubulin at the invasive margin of colorectal cancer: possible link to invasion.
pubmed:affiliation
Department of Pathology, Belarusian State Medical University, 220116, Dzerzhynsky Ave. 83, Minsk, Belarus. aportyanko@yahoo.com
pubmed:publicationType
Journal Article