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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2009-5-6
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pubmed:abstractText |
Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis(-/-) and Misrii(-/-) mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19359476-10407036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19359476-10443667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19359476-10523039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19359476-10571183,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19359476-15322528,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19359476-9916792
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7203-8
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19359476-Androgens,
pubmed-meshheading:19359476-Animals,
pubmed-meshheading:19359476-Anti-Mullerian Hormone,
pubmed-meshheading:19359476-Behavior, Animal,
pubmed-meshheading:19359476-Brain,
pubmed-meshheading:19359476-Cell Proliferation,
pubmed-meshheading:19359476-Female,
pubmed-meshheading:19359476-Gene Expression Regulation, Developmental,
pubmed-meshheading:19359476-Male,
pubmed-meshheading:19359476-Mice,
pubmed-meshheading:19359476-Mice, Knockout,
pubmed-meshheading:19359476-Motor Neurons,
pubmed-meshheading:19359476-Receptors, Peptide,
pubmed-meshheading:19359476-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:19359476-Sex Characteristics,
pubmed-meshheading:19359476-Spine
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pubmed:year |
2009
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pubmed:articleTitle |
Müllerian inhibiting substance contributes to sex-linked biases in the brain and behavior.
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pubmed:affiliation |
Department of Anatomy, University of Otago, Dunedin, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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