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rdf:type |
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lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0010124,
umls-concept:C0010132,
umls-concept:C0022661,
umls-concept:C0025936,
umls-concept:C0032105,
umls-concept:C0085140,
umls-concept:C0205263,
umls-concept:C0205374,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0547040,
umls-concept:C1701901
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pubmed:issue |
1
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pubmed:dateCreated |
2009-5-20
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pubmed:abstractText |
Converging findings support a role for extra-hypothalamic CRF in the mediation of the stress response. The influence of CRF in the amygdala is well established, while less is known of its role in other areas of the forebrain where CRF and CRF(1) receptors are also expressed. In the present study CRF was genetically induced to allow forebrain-restricted expression in a temporally-defined manner at any time during the mouse lifespan. This mouse model may offer the possibility to establish a model of the pathogenesis of recurrent episodes of depression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-5177
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pubmed:author |
pubmed-author:AngeliciOrnellaO,
pubmed-author:ArbanRobertoR,
pubmed-author:BortnerDonnaD,
pubmed-author:DomeniciEnricoE,
pubmed-author:GerrardPhilipP,
pubmed-author:LargeCharlesC,
pubmed-author:MangiariniLauraL,
pubmed-author:MansuyIsabelle MIM,
pubmed-author:MaraiaGabriellaG,
pubmed-author:Merlo-PichEmilioE,
pubmed-author:MugnainiManoloM,
pubmed-author:PericoMariaElisaM,
pubmed-author:UgoliniAnnarosaA,
pubmed-author:VicentiniElenaE
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pubmed:issnType |
Electronic
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-24
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pubmed:meshHeading |
pubmed-meshheading:19358863-Animals,
pubmed-meshheading:19358863-Anxiety,
pubmed-meshheading:19358863-Base Sequence,
pubmed-meshheading:19358863-Behavior, Animal,
pubmed-meshheading:19358863-Corticosterone,
pubmed-meshheading:19358863-Corticotropin-Releasing Hormone,
pubmed-meshheading:19358863-DNA Primers,
pubmed-meshheading:19358863-Dexamethasone,
pubmed-meshheading:19358863-Disease Models, Animal,
pubmed-meshheading:19358863-Female,
pubmed-meshheading:19358863-Gene Expression,
pubmed-meshheading:19358863-Male,
pubmed-meshheading:19358863-Mice,
pubmed-meshheading:19358863-Mice, Inbred C57BL,
pubmed-meshheading:19358863-Mice, Knockout,
pubmed-meshheading:19358863-Mood Disorders,
pubmed-meshheading:19358863-Prosencephalon,
pubmed-meshheading:19358863-RNA, Messenger,
pubmed-meshheading:19358863-Rats,
pubmed-meshheading:19358863-Stress, Physiological,
pubmed-meshheading:19358863-Synaptic Transmission
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pubmed:year |
2009
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pubmed:articleTitle |
Transient forebrain over-expression of CRF induces plasma corticosterone and mild behavioural changes in adult conditional CRF transgenic mice.
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pubmed:affiliation |
Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline S.p.A. Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy. elena.a.vicentini@gsk.com
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pubmed:publicationType |
Journal Article
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