|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2009-4-17
|
|
pubmed:abstractText |
An effort aimed at exploring structural diversity in the N-pyrazole-N'-naphthylurea class of p38 kinase inhibitors led to the synthesis and characterization of N-phenyl-N'-naphthylureas. Examples of these compounds displayed excellent inhibition of TNF-alpha production in vitro, as well as efficacy in a mouse model of lipopolysaccharide induced endotoxemia. In addition, perspective is provided on the role of a sulfonamide functionality in defining inhibitor potency.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
pubmed-author:BetageriRajR,
pubmed-author:BreitfelderSteffenS,
pubmed-author:ChristiansenI EIE,
pubmed-author:CirilloPier FPF,
pubmed-author:FadraTazmeenT,
pubmed-author:GaenzlerFaithF,
pubmed-author:GilmoreThomasT,
pubmed-author:GoldbergDaniel RDR,
pubmed-author:HickeyEugene RER,
pubmed-author:KamhiVictorV,
pubmed-author:KirraneThomasT,
pubmed-author:KroeRachel RRR,
pubmed-author:MoriakMonicaM,
pubmed-author:MossNeilN,
pubmed-author:NethertonMatthewM,
pubmed-author:PargellisChristopher ACA,
pubmed-author:PatelUsha RUR,
pubmed-author:QianKevin CKC,
pubmed-author:SharmaRajivR,
pubmed-author:SunSanxingS,
pubmed-author:SwinamerAlanA,
pubmed-author:TakahashiHidenoriH,
pubmed-author:TorcelliniCarolC,
pubmed-author:TsangMicheleM,
pubmed-author:XiongZhaomingZ
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2386-91
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:19356929-2-Naphthylamine,
pubmed-meshheading:19356929-Animals,
pubmed-meshheading:19356929-Chemistry, Organic,
pubmed-meshheading:19356929-Chemistry, Pharmaceutical,
pubmed-meshheading:19356929-Crystallography, X-Ray,
pubmed-meshheading:19356929-Drug Design,
pubmed-meshheading:19356929-Inhibitory Concentration 50,
pubmed-meshheading:19356929-Lipopolysaccharides,
pubmed-meshheading:19356929-Mice,
pubmed-meshheading:19356929-Models, Chemical,
pubmed-meshheading:19356929-Molecular Structure,
pubmed-meshheading:19356929-Protein Kinase Inhibitors,
pubmed-meshheading:19356929-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19356929-Urea,
pubmed-meshheading:19356929-p38 Mitogen-Activated Protein Kinases
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceutical, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA.
|
|
pubmed:publicationType |
Journal Article
|
