Linked Life Data

19356678

Source:http://linkedlifedata.com/resource/pubmed/id/19356678

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-4-9
pubmed:abstractText
There is increasing concern about the neurodegenerative and behavioral consequences of ozone pollution in industrialized urban centers throughout the world and that women may be more susceptible to brain neurodegenerative disorders. In the present study we have investigated the effects of chronic (30 or 60 days) exposure to ozone on olfactory perception and memory and on levels of lipid peroxidation, alpha and beta estrogen receptors and dopamine beta-hydroxylase in the olfactory bulb in ovariectomized female rats. The ability of 17beta-estradiol to prevent these effects was then assessed. Results showed that ozone exposure for 30 or 60 days impaired formation/retention of a selective olfactory recognition memory 120 min after exposure to a juvenile stimulus animal with the effect at 60 days being significantly greater than at 30 days. They also showed impaired speed in locating a buried chocolate reward after 60 days of ozone exposure indicating some loss of olfactory perception. These functional impairments could all be prevented by coincident estradiol treatment. In the olfactory bulb, levels of lipid peroxidation were increased at both 30- and 60-day time-points and numbers of cells with immunohistochemical staining for alpha and beta estrogen receptors, and dopamine beta-hydroxylase were reduced as were alpha and beta estrogen receptor protein levels. These effects were prevented by estradiol treatment. Oxidative stress damage caused by chronic exposure to ozone does therefore impair olfactory perception and social recognition memory and may do so by reducing noradrenergic and estrogen receptor activity in the olfactory bulb. That these effects can be prevented by estradiol treatment suggests increased susceptibility to neurodegenerative disorders in aging women may be contributed to by reduced estrogen levels post-menopause.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-7544
pubmed:author
pubmed:issnType
Electronic
pubmed:day
31
pubmed:volume
159
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
940-50
pubmed:meshHeading
pubmed-meshheading:19356678-Air Pollutants, pubmed-meshheading:19356678-Animals, pubmed-meshheading:19356678-Dopamine beta-Hydroxylase, pubmed-meshheading:19356678-Estradiol, pubmed-meshheading:19356678-Estrogen Receptor alpha, pubmed-meshheading:19356678-Estrogen Receptor beta, pubmed-meshheading:19356678-Estrogens, pubmed-meshheading:19356678-Female, pubmed-meshheading:19356678-Lipid Peroxidation, pubmed-meshheading:19356678-Memory Disorders, pubmed-meshheading:19356678-Olfactory Bulb, pubmed-meshheading:19356678-Olfactory Perception, pubmed-meshheading:19356678-Ovariectomy, pubmed-meshheading:19356678-Oxidative Stress, pubmed-meshheading:19356678-Ozone, pubmed-meshheading:19356678-Rats, pubmed-meshheading:19356678-Rats, Wistar, pubmed-meshheading:19356678-Recognition (Psychology), pubmed-meshheading:19356678-Social Perception
pubmed:year
2009
pubmed:articleTitle
Estradiol prevents ozone-induced increases in brain lipid peroxidation and impaired social recognition memory in female rats.
pubmed:affiliation
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Apartado Postal 70250, Mexico 04510, D.F, Mexico. rguevara@servidor.unam.mx
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't