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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-4-9
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pubmed:abstractText |
An efficient synthesis of 3-substituted crotonaldehydes via alkyne-enol ether cross-metathesis in the presence of CuSO(4) and in aqueous medium was developed. Crotonaldehydes were obtained in good yields from terminal aryl-alkynes as well as from terminal alkyl-alkynes. All of the reactions were carried out under microwave irradiation and were completed in a few minutes. Water was used as the cosolvent, making this approach safer, economic, and desiderable from an enviromental point of view.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1520-6904
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3172-4
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pubmed:meshHeading |
pubmed-meshheading:19354326-Aldehydes,
pubmed-meshheading:19354326-Alkenes,
pubmed-meshheading:19354326-Alkynes,
pubmed-meshheading:19354326-Copper Sulfate,
pubmed-meshheading:19354326-Ethers,
pubmed-meshheading:19354326-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19354326-Molecular Structure,
pubmed-meshheading:19354326-Solutions,
pubmed-meshheading:19354326-Stereoisomerism,
pubmed-meshheading:19354326-Structure-Activity Relationship,
pubmed-meshheading:19354326-Water
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pubmed:year |
2009
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pubmed:articleTitle |
Alkyne-enol ether cross-metathesis in the presence of CuSO(4): direct formation of 3-substituted crotonaldehydes in aqueous medium.
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pubmed:affiliation |
Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via A. de Gasperi 2, 53100 Siena, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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