Source:http://linkedlifedata.com/resource/pubmed/id/19353263
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-7-23
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| pubmed:abstractText |
Little is known about the importance of dose timing to successful antiretroviral therapy (ART). In a cohort comprised of Chinese HIV/AIDS patients, we measured adherence among subjects for 6 months using three methods in parallel: self-report using a visual analog scale (SR-VAS), pill count, and electronic drug monitors (EDM). We calculated two adherence metrics using the EDM data. The first metric used the proportion of doses taken; the second metric credited doses as adherent only if taken within a 1-h window of a pre-specified dose time (EDM 'proportion taken within dose time'). Of the adherence measures, EDM had the strongest associations with viral suppression. Of the two EDM metrics, incorporating dose timing had a stronger association with viral suppression. We conclude that dose timing is also an important determinant of successful ART, and should be considered as an additional dimension to overall adherence.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1573-3254
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
14
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
785-93
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| pubmed:meshHeading |
pubmed-meshheading:19353263-Adult,
pubmed-meshheading:19353263-Anti-HIV Agents,
pubmed-meshheading:19353263-Asian Continental Ancestry Group,
pubmed-meshheading:19353263-CD4 Lymphocyte Count,
pubmed-meshheading:19353263-China,
pubmed-meshheading:19353263-Dose-Response Relationship, Drug,
pubmed-meshheading:19353263-Drug Administration Schedule,
pubmed-meshheading:19353263-Female,
pubmed-meshheading:19353263-Follow-Up Studies,
pubmed-meshheading:19353263-HIV Infections,
pubmed-meshheading:19353263-Humans,
pubmed-meshheading:19353263-Longitudinal Studies,
pubmed-meshheading:19353263-Male,
pubmed-meshheading:19353263-Medication Adherence,
pubmed-meshheading:19353263-Middle Aged,
pubmed-meshheading:19353263-Socioeconomic Factors,
pubmed-meshheading:19353263-Time Factors,
pubmed-meshheading:19353263-Viral Load
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Importance of dose timing to achieving undetectable viral loads.
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| pubmed:affiliation |
Center for International Health and Development, Boston University of Public Health, Boston, MA 02118, USA. cgill@bu.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|