| pubmed-article:19353243 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C0021246 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C1538354 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:19353243 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:19353243 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:19353243 | pubmed:dateCreated | 2009-12-3 | lld:pubmed |
| pubmed-article:19353243 | pubmed:abstractText | This study was designed to investigate whether indomethacin and NGX6 synergistically inhibit the growth and invasiveness of human colon cancer cells (HT-29 and SW620) and to elucidate the molecular mechanism of their action. Cell proliferation was assessed by MTT assay. Cell apoptosis was assessed by acridine orange/ethidium bromide staining (AO-EB) and annexin-V-FITC/PI assay. Invasive behaviors of colorectal cancer cells were examined by cell adhesion, migration, and invasion assays. Gap junctional intercellular communication (GJIC) was assessed by the scrape-loading/dye transfer technique. The subcellular localization and expression of beta-catenin protein was examined by immunofluorescence staining and western blot analysis, respectively. Indomethacin and NGX6 had a synergistic effect on inhibiting proliferation and invasiveness of colon cancer HT-29 and SW620 cells, restoring GJIC of HT-29 and SW620, and suppressing translocation of beta-catenin from the nucleus and cytoplasm to the plasma membrane. However, they did not have synergistic effects on enhancing apoptosis and suppressing extracellular matrix adhesion of HT-29 and SW620 cells. Indomethacin and NGX6 inhibit the proliferation and invasiveness of HT-29 and SW620 colon cancer cells by attenuating the WNT/ss-catenin signaling pathway. | lld:pubmed |
| pubmed-article:19353243 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19353243 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19353243 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19353243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19353243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19353243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19353243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19353243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19353243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19353243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19353243 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19353243 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19353243 | pubmed:issn | 1573-4919 | lld:pubmed |
| pubmed-article:19353243 | pubmed:author | pubmed-author:WangXiaoyanX | lld:pubmed |
| pubmed-article:19353243 | pubmed:author | pubmed-author:ShenShourongS | lld:pubmed |
| pubmed-article:19353243 | pubmed:author | pubmed-author:HiiT KTK | lld:pubmed |
| pubmed-article:19353243 | pubmed:author | pubmed-author:LianPingP | lld:pubmed |
| pubmed-article:19353243 | pubmed:author | pubmed-author:WuMinghuaM | lld:pubmed |
| pubmed-article:19353243 | pubmed:author | pubmed-author:XiaoZhimingZ | lld:pubmed |
| pubmed-article:19353243 | pubmed:author | pubmed-author:LiaoMantianM | lld:pubmed |
| pubmed-article:19353243 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19353243 | pubmed:volume | 330 | lld:pubmed |
| pubmed-article:19353243 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19353243 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19353243 | pubmed:pagination | 71-81 | lld:pubmed |
| pubmed-article:19353243 | pubmed:dateRevised | 2011-10-13 | lld:pubmed |
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| pubmed-article:19353243 | pubmed:meshHeading | pubmed-meshheading:19353243... | lld:pubmed |
| pubmed-article:19353243 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19353243 | pubmed:articleTitle | Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. | lld:pubmed |
| pubmed-article:19353243 | pubmed:affiliation | Department of Digestion Medicine, The Third Affiliated Hospital of Xiang Ya School of Medicine, Central South University, Changsha, 410078, Hunan, People's Republic of China. | lld:pubmed |
| pubmed-article:19353243 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19353243 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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