Linked Life Data

19351953

Source:http://linkedlifedata.com/resource/pubmed/id/19351953

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
65
pubmed:dateCreated
2009-4-8
pubmed:abstractText
The identification of the molecular mechanisms underlying neuronal survival continues to be the subject of intensive research efforts as the incidence of age-related neurodegenerative diseases rises. Amid a complex mélange of environmental and genetic factors that contribute to disease manifestation, much effort has been dedicated to understanding the underlying signaling mechanisms that regulate neuronal survival. A recent study by Yang et al. sheds new light on an intracellular quality-control system that regulates the constitutive abundance of a neuronal survival factor through chaperone-mediated autophagy and links the deregulation of this pathway to Parkinson's disease. Although the primary function of autophagy in most cell types has commonly been thought to be an adaptive response to starvation, it has been proposed that proper functioning of this system is essential for neuronal survival and that its deregulation leads to neurodegeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1937-9145
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
pe21
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Parkinson's disease: to live or die by autophagy.
pubmed:affiliation
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
pubmed:publicationType
Journal Article, Review