|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2009-4-16
|
|
pubmed:abstractText |
Wilms' tumor protein (WT1) is overexpressed in most leukemias and many solid tumors and is a promising target for tumor immunotherapy. WT1 peptide-based cancer vaccines have been reported but have limited application due to HLA restriction of the peptides. We sought to vaccinate using adenoviral (Ad) vectors encoding tumor-associated antigens such as WT1 that can stimulate tumor-associated antigen-specific immunity across a broad array of HLA types and multiple class I and class II epitopes.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
pubmed-author:AmalfitanoAndreaA,
pubmed-author:ChaoNelsonN,
pubmed-author:ClayTimothy MTM,
pubmed-author:HartmanZachary CZC,
pubmed-author:LabrecheHeather GHG,
pubmed-author:LeiGangjunG,
pubmed-author:LyerlyH KimHK,
pubmed-author:McKinneyMatthewM,
pubmed-author:MorseMichael AMA,
pubmed-author:NiedzwieckiDonnaD,
pubmed-author:OsadaTakuyaT,
pubmed-author:WooChristopher YCY,
pubmed-author:YangXiao YiXY
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2789-96
|
|
pubmed:meshHeading |
pubmed-meshheading:19351755-Animals,
pubmed-meshheading:19351755-Cancer Vaccines,
pubmed-meshheading:19351755-Cell Line, Tumor,
pubmed-meshheading:19351755-Dendritic Cells,
pubmed-meshheading:19351755-Genetic Vectors,
pubmed-meshheading:19351755-Humans,
pubmed-meshheading:19351755-Immunotherapy,
pubmed-meshheading:19351755-Leukemia,
pubmed-meshheading:19351755-Mice,
pubmed-meshheading:19351755-Mice, Inbred C57BL,
pubmed-meshheading:19351755-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:19351755-WT1 Proteins
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine.
|
|
pubmed:affiliation |
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
