Linked Life Data

19351353

Source:http://linkedlifedata.com/resource/pubmed/id/19351353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-4-8
pubmed:abstractText
The existence of a primitive, elemental form of CNS arousal, "generalized arousal," has been hypothesized; it has been given an operational definition, and a high throughput assay has been assayed for it in mice. Many of the ascending and descending neuroanatomical pathways are fairly well understood. To begin experiments that might have potential implications for therapeutic measures, mice were rendered anoxic and it was shown that the assay can demonstrate behavioral abnormalities not detected with a standard neurological screen. These behavioral deficiencies are reminiscent of "sundowning," a form of dementia seen in hospitalized elderly patients. Electrical stimulation of neurons in medial thalamic cell groups can increase activity in the generalized arousal assay. Current studies include attempts to achieve temporal patterns of electrical stimulation that would take advantage of nonlinear properties of ascending arousal pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24-31
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Definition of arousal and mechanistic studies in intact and brain-damaged mice.
pubmed:affiliation
Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10065, USA.
pubmed:publicationType
Journal Article, Review