Linked Life Data

19351352

Source:http://linkedlifedata.com/resource/pubmed/id/19351352

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-4-8
pubmed:abstractText
The corticothalamic system is organized to play a key role in synchronizing the activities of thalamic and cortical neurons. Its synapses dominate the inputs to relay cells and to the GABAergic cells of the reticular nucleus; its organization in focused and diffuse projections promotes both coherent activity of relay neurons and the spread of activity across the cortex and thalamus. The capacity of relay neurons to operate in voltage-dependent tonic or burst mode permits corticothalamic inputs to directly excite the relay cells or indirectly inhibit them via the reticular nucleus. This enables the corticothalamic projection to synchronize high- or low-frequency oscillatory activity, respectively, in the thalamo-corticothalamic network. Differences in the subunit composition of AMPA receptors at synapses formed by branches of the same corticothalamic axon in the reticular nucleus and dorsal thalamus are an important element in the capacity of the cortex to synchronize low-frequency oscillations in the network. Intrinsic voltage-gated calcium channels of different kinds expressed in the relay neurons form a substrate for corticothalamic interactions with the relay cells that promote high- or low-frequency oscillations. Focused corticothalamic axons arising from layer VI cortical cells and diffuse corticothalamic axons arising from layer V cortical cells, in conjunction with the core and matrix cells of the dorsal thalamus, form a substrate for synchronization of widespread populations of cortical and thalamic cells during high-frequency oscillations that underlie discrete conscious events.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Synchrony in the interconnected circuitry of the thalamus and cerebral cortex.
pubmed:affiliation
Center for Neuroscience, University of California, Davis, California 95616, USA. ejones@ucdavis.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural